胺碘酮联合尤尼清对快速心房颤动转复的疗效观察

Effect of Youniqing combined with Amiodarone on cardioversion of atrial fibrillation

目的观察尤尼清(环磷腺苷葡胺meglumine cyclic adenylate,MCA)加强胺碘酮对阵发性快速心房颤动的转复效果。方法将该院急诊科2006年1月～2009年1月198例阵发性心房颤动患者分为胺碘酮治疗组(A组)和尤尼清+胺碘酮治疗组(B组)。观察治疗12、24和72h转律成功率及有效控制心室率时间。结果尤尼清+胺碘酮组12、24和72h转律成功率分别为76.47%、88.24%和90.20%,胺碘酮组12、24和72h转律成功率分别为63.54%、76.04%和79.17%,差异有统计学意义(P<0.05)。尤尼清+胺碘酮组6h和12h心室率控制率分别为86.31%和99.02%,明显高于胺碘酮组69.79%和90.63%,两组相比差异有统计学意义(P<0.01)。结论对阵发性快速心房颤动患者进行胺碘酮转律治疗时,加用尤尼清可增加转律成功率,缩短转律所需时间,并有效降低心室率。

[Objective] To observe whether the Youniqing （meglumine cyclic adenylate, MCA） could enhance the recovery effect of Amiodarone on paroxysmal atrial fibrillation （AF）. [Methods] From January 2006 to January 2009, a total of 198 patients with paroxysmal atrial fibrillation in emergency department of shengjing hospital were divided into two group： group A （Amiodarone） and group B （Youniqing and Amiodarone）. The rate of cardioversion of AF and the effective control time of ventrieular rate in 12, 24 and 72 h after therapy was investigated. [Results] The rate of cardioversion of AF is 76.47%, 88.24% and 90.20%, respectively, at 12, 24 and 72 h in group B, and 63.54%, 76.04% and 79.17% in group A. There was statistical Significance difference （P 〈0.05）. The ventricular rate in group B （86.31% and 99.02%） is significandy higher than group A （69.79% and 90.63%） at 6 h and 12 h. The difference is of statistical significance （P 〈0.05）. [Conclusions] The results of this study suggest that in the therapy to AF patients, the combination of amiodarone with Youniqing can raise the achievement ratio of cardioversion, shorten the cardioversion time, and decrease the ventrieular rate.