实时超声造影检测兔微小VX2肝肿瘤的实验研究

Detection of minute hepatic VX2 tumor:an experimental study with real-time ultrasound contrast

目的评估实时超声造影对最大径≤10mm的兔肝VX2微小肿瘤的检出效能。方法实时超声造影检查30只肝脏接种2个VX2肿瘤的新西兰大白兔,造影剂为注射用六氟化硫微泡(声诺维),成像技术采用对比脉冲序列。观察兔肝VX2肿瘤的时间推移影像特征,并与普通超声及病理检查比较。结果30只动物肝脏大体病理检查共检出39个肿瘤,大小4.2～9.1mm。其中<5.0mm的肿瘤结节造影前检出1个,造影后检出14个;5.0～10.0mm的肿瘤结节造影前检出4个,造影后检出17个;微小肿瘤检出率从造影前的12.8%提高到造影后79.5%。结论实时超声造影比普通超声显著提高了10.0mm以下兔微小VX2肿瘤的检出率。

Objective To evaluate the diagnostic performance of real - time contrast - enhanced ultrasound （CEUS） in diagnosing minute VX2 hepatic tumors with diameter ≤ 10.0 ram. Methods Tumor block transplanting methods was used to make the rabbit VX2 carcinoma model, and the tumor in rabbit＇s liver was verified by pathological section. Base -ultrasound（US） and CEUS were applied to detect rabbit VX2 tumors. The diagnostic performances of CEUS and US in evaluating rabbit VX2 tumors were analyzed and compared. Results Thirty - nine tumors were verified on pathological section. The detection rates of baseline and contrast ultrasound images were 12.8% and 79.5% respectively. CEUS yiel- ded significantly higher detection rate than that of US. Conclusion Real - time CEUS significantly raises the detection rate of VX2 liver tumors less than 10.0 mm in diameter.