氟马西尼用于小儿全麻催醒的临床研究

Clinical study on flumazenil using for analepsia of children after general anesthesia

目的分别比较氟马西尼和纳洛酮用于小儿全麻后催醒复苏的效果及不良反应。方法全麻术后将需要催醒的30例小儿患者随机分成两组,每组15例,Ⅰ组选用氟马西尼,用量为0.004～0.007mg/kg,60s内清醒程度未达到要求再追加半量。Ⅱ组选用催醒药为纳洛酮,用量为0.006～0.008mg/kg,再次用药用半量。同时观察患儿的表情和心血管系统的变化,询问各组清醒程度及痛觉。结果Ⅰ组患者在5min内有80%达到完全清醒,并保持较好的镇静、镇痛效果。Ⅱ组患儿在5min内只有近一半达到完全清醒,但容易出现躁动,痛觉明显。结论氟马西尼用于小儿全麻后催醒复苏效果优于纳洛酮,并保持较好的镇静、镇痛作用。

Objective To discuss the analeptic effects of flumazenil/naloxone in childish patients for recovery from general anesthesia. Methods Thirty childish patients needing analeptic were randomly divided into two groups. The patients in group I received flumazenil（0. 004 -0. 007 mg/kg, iv）, and patients in group Ⅱ received naloxone（0. 006 - 0. 008 mg/kg, iv）. When patients could not be awakened in 60 seconds, then a half of the first dose was given to them once more. The expression of patients and changes in cardiovascular system were assessed, the alert- ness score and the sense of pain were also estimated. Results In group Ⅰ , 80 percent of patients could be awoke in 5 minutes with satisfied sedative and analgesic effect. In group Ⅱ, about half of patients could be awoke, but they appeared anxiety and had obvious sense of pain. Conclusion Flumazenil has better analeptic effect than naloxone in childish patients after general anesthesia, and it can keep good sedative and analgesic effect.