小儿原发性肾病综合征脂质紊乱与蛋白代谢异常的关系

The relationship between abnormal lipid and abnormal protein metabolism in children with idiopathic nephrotic syndrome

目的研究小儿原发性肾病综合征（ＩＮＳ）与蛋白代谢异常的关系。方法检测６８例小儿ＩＮＳ７项脂质指标及５项蛋白代谢参数。采用ＳＤＳＰＡＧＥ电泳检测其尿蛋白类型。结果ＩＮＳ小儿存在明显脂质紊乱，具有动脉粥样硬化、冠心病及进行性肾脏损害的危险因素结论尿白蛋白排泄率增加或中分子尿蛋白是脂质紊乱重要原因。尿白蛋白排泄率与脂质紊乱关系密切。

bjective To study the relationship between abnormal lipid and abnormal protein metabolism in children with idiopathic nephrotic syndrome (INS). Methods 7 lipid parameters and 5 protein metabolism parameters were determined in 68 INS children. Sodium dodecylsulphate gel electropheresis (SDSPAGE) was used to determine urinary protein types. Results Obviously abnormality of lipid was seen in INS children which possessed the risk factors leading to arteriosclerosis、coronary disease and progressive renal damage. Conclusion Increasing urinary albumin excretion (UAE) or medium molecule proteinuria may be the main causes of abnormal lipid. UAE is closely related to the abnormality of lipid.