摘要
探讨高剂量白介素—Ⅱ在治疗晚期恶性肿瘤中的作用。将高剂量白介素—Ⅱ(每次100万μ~200万μ)用200mL生理盐水稀释后静脉滴注,或用20mL生理盐水稀释后腹腔注射,或用5mL~10mL生理盐水稀释后瘤块局部注射。并应用流式细胞术检测T淋巴细胞亚型和NK细胞比值。17例晚期恶性肿瘤中,显效(CR)0例,有效(PR)5例,好转(MR)4例,无改变(NC)6例,进展(PD)2例。有效率(CR+PR)为29.4%(5/17)。应用高剂量白介素—Ⅱ后的CD+4/CD+8和CD56的比值比应用前有所提高,经统计学处理P<0.05,有显著差异,具有统计学意义。高剂量白介素—Ⅱ可改善患者的生存质量,提高机体免疫功能和增强NK细胞杀伤肿瘤细胞的活性。
To investigate the effect of high-dose IL-2 on advanced malignancies we made this study.Method:IL-2(1--2x10units daily) was use as intrawenus,abdominocentesis or local infusion.For all patients T lymphocyte subsets and NK cell were measured by flow cytometery.Resultis:5/17 patients abtained PR,4/17 MR,2/17 PD.The percentage of responding patients was 29.4%.The pencentage of CD 56 + cell and the ratio of CD 4 + cell/CD 8 + cell increase significantly.Conclusion:High-dose IL-2 can improve patient’s living quality,intense the immunology function and inhance the killing activity of NK cell on malignancy.
出处
《山西临床医药》
1998年第3期147-149,共3页
Shanxi Clinical Medicine
关键词
剂量
晚期
肿瘤
白细胞介素
疗效
High-close IL-2 Advanced malignancy Subtype of T-lymphocyte NK cell