INT细胞毒检测对急性白血病治疗指导价值的研究

Significance of INT assay to guide the treatment of acute myeloblastic leukemia

采用对碘硝基比色法（ＩＮＴ法），观察体外药敏和体内疗效的关系，以及化疗药物细胞毒性与常用血液学指标的相关性。研究结果显示，用ＩＮＴ法体外敏感试验对个体化的选择用药有一定的帮助。性别、年龄、血红蛋白。

The cytotoxicity of daunorubicin (DNR),cytosine arabinoside(AraC),etopside(VP16)and harringtonine(H)to leukemic cells was measuredThe INT assay method was applied in vitroThe results indicated that INT chemosensitivity assay can be used to screen the antileukemia drugs for chemotherapy and that no diference was found in CI between male and female patientsThere were no linear correlations between CI and patients' ages,Hb,WBC and blasts in the bone narrow before chemotherapy