沙枣多糖对免疫抑制小鼠的调节作用

Immunoloregulation Effect of Elaeagnus angustifolia L. Polysaccharides in Immunosuppressive Mice

[目的]研究沙枣多糖(EAPS)对免疫抑制小鼠免疫功能的影响。[方法]以环磷酰胺(Cy)作免疫抑制剂建立小鼠免疫抑制模型,进行免疫脏器指数的检测、碳粒廓清试验、血清溶血素形成和迟发型超敏反应,探讨沙枣多糖对免疫功能低下小鼠的影响。[结果]沙枣多糖能明显提高正常小鼠脾脏指数、胸腺指数及免疫抑制小鼠脾脏指数;增强正常小鼠和免疫抑制小鼠单核巨噬细胞系统吞噬功能,恢复免疫抑制小鼠迟发型超敏反应,促进溶血素的生成。[结论]沙枣多糖可对抗Cy所致的免疫抑制,明显增强小鼠免疫功能。

[ Objective] The aim was to research the effect of Elaeagnus angustifolia L. polysaceharides （EAPS） on immune functions of immanosuppressive mice. [ Method ] Taking cyelophosphamide as immunosuppressive agents to construct the immunosuppression model of mice, immune organs index was determined, carbon clearance experiment, serum hemolysin formation and delayed type hypersensitivity were carried out, the effect of Elaeagnus angustifolia L. polysaccharides on immune hypofunetion mice was discussed. [ Result ] Elaeagnus angustifolia L. polysaccharides markedly increased the immunity function by increasing the spleen and thymus index of mice, increasing the phagocytosis of mononuclear phagocyte system, recovering the delayed type hypersensitivity of immunosuppressive mice and stimulating hemolysin formation. [ Conclusion] Elaeagnus angustifolia L. polysaceharides can obviously increase the immunity function of mice.