摘要
采用LSAB免疫组化法检测66例大肠癌中PCNA和CEA的阳性表达。结果:PCNA阳性57例(86.4%),CEA阳性55例(83.3%)。中等分化大肠癌与高分化大肠癌,其PCNA阳性表达有非常显著性差异(P<0.01),而CEA阳性表达在大肠癌高、中和低分化组间有显著性差异(P<0.05)。PCNA和CEA阳性表达在大肠癌分级中起到重要的作用。Dukes′B期和Dukes′C期,其PCNA和CEA的阳性表达均有显著性差异(P<0.05)。结果表明PCNA和CEA阳性表达的大肠癌,阳性强度越高,说明癌的分化程度越低,浸润性强,转移快。两者同时检测,起到互补作用,可作为估价预后的一个有效指标。
cases of large intestine carcinoma were studied using LSAB immunohistochemistry to detect proliferating cell nuclear antigen (PCNA) and carcinoembryonic antigen (CEA).Ressults:57 cases (86.4%) were positive for PCNA and 55 cases ( 83.3% ) were positive for CEA.The difference of PCNA positive rates had remarkable statistically significance between medial differentiated and poorly differentiated carcinoma ( P <0.01),as well as positive rate of CEA among three grades of the carcinoma.Between stages of Dukes′B and Dukes′C,the differences of postive rate of PCNA and CEA also had statistically significance( P < 0.05 ).A combinated detection of PCNA and CEA would be useful for indication of prognosis in large intestine carcinoma.
出处
《实用癌症杂志》
1998年第2期110-111,共2页
The Practical Journal of Cancer