妊娠相关蛋白A基因多态性与早发冠心病相关性研究

Relationship between PAPP-A gene polymorphism and premature coronary heart disease

目的:探讨妊娠相关蛋白A(PAPP-A)第14外显子A/C(Tyr/Ser)基因多态性与我国早发冠心病的相关性。方法:早发冠心病(病例组)85例,非冠心病(对照组)93例,采用聚合酶链反应-限制性片段长度多态性方法(PCR-RFLP)分析PAPP-A基因多态性。结果:病例组PAPP-A基因型中CC型频率高于对照组,但2组总的基因型频率分布差异有统计学意义(χ2=10.302,P=0.016),A、C等位基因频率差异有统计学意义(P<0.05)。结论:PAPP-A第14外显子A/C(Tyr/Ser)基因多态性可能与我国早发冠心病的易感性有关。

Objective：To investigate the relationship between pregnancy-associated plasma protein A （PAPP- A） gene polymorphism and premature coronary heart disease in Chinese. Method： Eighty-five patients of premature coronary heart disease （CHD） and ninety-three controls were enrolled and polymerase chain reaction restriction fragement length polymorphism （PCR-RFLP） was used to analysis PAPP-A gene polymorphism. Result： Compared to controls, patients with premature CHD had higher frequencies of CC genotype. Then there were significant differences in the distribution of genotype and allele frequency （P〈0.05）. Conclusion：The gene in the exon 14 polymorphism of PAPP-A had some associated with premature CHD in Chinese.