区域动脉化疗加^(60)Co外照射治疗晚期直肠癌

Advanced Rectal Cancer Treated By Regional Intra arterial Chemotherapy Plus Radiation

１９８５年至１９９５年采用区域动脉插管化疗加６０Ｃｏ外照射的方法治疗晚期直肠癌２５例，其中术后复发１３例，单纯造瘘９例，部分切除３例。化疗每次用顺铂２０ｍｇ，５－Ｆｕ５００ｍｇ，二者交替，１２天为１周期，２周期为１个疗程，化疗后行６０Ｃｏ外照射，肿瘤量５０～６０Ｇｙ／６～７周。全组１年、２年、３年生存率分别为５３．８％、３４．６％、８．０％，而单纯造瘘组２年生存率（３８．５％）高于术后复发组（３０．８％）。结果提示，对不能切除的晚期直肠癌较适宜采用这种治疗方法，而区域动脉化疗加放疗能有效地改善晚期直肠癌的预后。

From 1985 to 1995,25 patients with advanced rectal cancer were treated by regional intra arterial chemotherapy plus radiation.In these patients,the postoperative recurrence of pelivs,only building fistula and partial resection were 13、9、3 cases respectively.The chemotherapy regime included infusion of cisplatine (20 mg) and 5 Fu (500 mg) on alternate days,12 days as one cycle.Irradition started after the second cycle.The tumor dose was 50～60 Gy.The survival rates of 1,2,3 years in all patients were 53.8%,34.6%,8.0%.The 2 years survival rates (38.5%) in building fistula group was higher than that (30.8%) in postoperative pelvic recurrence group.The results indicate that for unresection advanced rectal cancer the treatment with regional intra arterial chemotherapy plus radiation might be helpful.