PCNA与AFP在人肝癌组织中的表达及其预后意义

Expression of Proliferating Cell Nuclear Antigen and Alpha Fetoprotein in Hepatocellular Carcinoma and Its Clinical Significance.

作者采用免疫组化染色技术，检测５２例肝癌组织中ＰＣＮＡ和ＡＦＰ的表达。结果表明ＰＣＮＡ和ＡＦＰ在癌组织中的表达率明显高于癌旁组织（Ｐ＜０．０５）；ＰＣＮＡ与ＡＦＰ在癌组织中的表达率存在一定的相关性（ｒ＝０．３７，Ｐ＜０．０５），癌组织中ＰＣＮＡ阳性表达率越高（≥４５％），患者生存期越短。作者认为ＡＦＰ基因的激活能促进癌性增殖；ＰＣＮＡ在癌组织中表达率越高，反映了细胞增殖越活跃，倍增时间越短，肿瘤细胞的生物学特性表现为细胞分化程度低，恶性程度高，组织侵袭力强，复发及远处转移早，患者临床预后差。

The expression of PCNA and AFP were detected in 52 cases of hepatocellular carcinoma(HCC)with immunohistochemistry method.It was found that the expression of PCNA and AFP in cancers was significantly higher than those in non cancerous adjacent tissues( P <0.05);the expression of AFP was correlated with that of PCNA(r=0.37, P <0.05);those patients with a PCNA score greater than or equal to 45 percent had significantly less survival rates.These results suggest that the activated AFP gene could promote the increase in the number of tumor cells;Proliferation activity definded by PCNA immunohistochemical study was related to invasiveness and an aggressive tumor behavior.The findings may therefore help to explain the higher recurrence and poor survial rate of the patients.