期刊文献+

Th17细胞在移植排斥反应中的作用

原文传递
导出
摘要 以往认为,参与细胞免疫的CD4^+T淋巴细胞可分为Th1和Th2等细胞亚群,他们各自以不同的角色参与免疫应答。近年来,研究发现了一类新型的效应性T淋巴细胞亚群Th17细胞。Th17细胞是一种炎症细胞,介导炎症反应,主要分泌白细胞介素17(IL-17)。而移植排斥反应的本质就是炎症反应。因此,我们对Th17细胞及其分泌的细胞因子IL-17在移植排斥反应中的作用,综述如下。
出处 《中华器官移植杂志》 CAS CSCD 北大核心 2009年第6期383-384,共2页 Chinese Journal of Organ Transplantation
基金 江苏省兴卫工程医学领军人才项目(13543)
  • 相关文献

参考文献20

  • 1Park H,Li Z,Yang XO,et al.A distinct liesge of CD4 T cells regulates inflammation by producing interleukin 17.Nat Immunol,2005,6(11):1133-1141.
  • 2Laan M,Lotvall J,Chung KF,et al.IL-17-induced cytokine release in human bronchial epithelial cells in vitro:role of mitogen-activated protein (MAP) kinases.Br J Pharmacol,2001,133(1):200-206.
  • 3Cua DJ,Sherlock,Chert Y,et al.Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain.Nature,2003,421 (6924); 744-748
  • 4Hoeve MA,Savage ND,de Boer T,et al.Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells.Eur J Immunol,2006,36(3):661-670.
  • 5Veldhoen M,Hocking RJ,Atkins CJ,et al.TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells.Immunity,2006,24 (2):179-189.
  • 6Mangan PR,Harfington LE,O'Quinn DB,et al.Transforming growth factor-beta induces development of the T (H)17 lineage.Nature,2006,441(7090):166-178.
  • 7Rangachari M,Mauermann N,Marty RP,et al.T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17.J Exp Med,2006,203(8):2009-2019.
  • 8Moseley TA,Haudenschild DR,Rose L,et al.Interleukin-17 family and IL-17 receptors.Cytokine Growth Factor Rev,2003,14(2):155-174.
  • 9Yao Z,Fanslow WC,Seldin MF,et al.Herpesvirus Saimiri encodes a new cytokine,IL-17,which binds to a novel cytokine receptor.Immunity,1995,3(6):811-821.
  • 10Attur MG,Patel RN,Abramson SB,et al.Interleukin-17 up-regulation of nitric oxide production in human osteoarthritis cartilage.Arthritis Rheum,1997,40(6):1050-1053.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部