睾丸精原细胞瘤的疗效及预后因素分析

Analysis of the Treatment Results and Prognostic Factors in Testicular Seminoma

作者分析了５０例睾丸精原细胞瘤的疗效及预后因素。术后单纯放疗２４例，放疗加化疗１３例，两组的５年、１０年生存率分别为９１．７％及８４．３％，Ｐ＞０．０５，单纯化疗１３例，５年生存率为９０．９％，与放疗、化疗组相比，Ｐ＞０．０５。年龄＜４０岁和≥４０岁的病例的５年、１０年生存率分别为９５．７％和６８．８％，Ｐ＜０．０５。结果表明，Ⅰ期睾丸精原细胞瘤病例手术后宜行单纯放疗，若复发，可行放疗加化疗；年龄较轻的病例生存率较高；β－绒毛膜促性腺激素水平、隐睾及隐睾部位与生存率关系不大。

The treatment results and prognostic factors in 50 patients with testicular seminoma were analysed.Among them,24 patients were treated with surgery plus postoperative radiotherapy(RT),13 with chemoradiation therapy,the 5,10 year survival rates of the two groups were 91.7% and 84.3% respectively ( P >0.05),in 13 cases treated with chemotherapy alone,the 5 year survival rate was 90.9%.In comparison with 84.3% of 13 patients treated with chemoradiation therapy, there was no statistically significant difference ( P >0.05). The 5,10 year survival rates of age< and ≥40 were 95.7% and 68.8% respectively ( P <0.05).The results showed that patients with stage Ⅰ testicular seminoma have better to receive postoperative RT,RT or chemoradiation therapy is effective for recurrent seminoma.The younger the patients are, the better survival rates will be.There is no association of β HCG、cryptorchid seminoma and its location with survival rates.