摘要
为了探讨Ｐ１６抑癌基因与卵巢浆液性肿瘤生物学行为的关系，应用免疫组织化学方法检测了６５例卵巢浆液性癌、１８例交界性瘤、１７例卵巢浆液性瘤中Ｐ１６基因的表达。结果显示：浆液性癌、交界瘤和浆液性瘤表达的阳性率分别为４４６２％、６６６７％和７６４７％（Ｐ＜０００５）；在高分化、中分化和低分化的卵巢浆液性癌中表达的阳性率分别为５６％、４１３８％和２７２７％（Ｐ＜０００５），显示Ｐ１６基因的阳性率随着病理分极的上升而降低。Ｐ１６在６５例卵巢癌的淋巴结中有转移的阳性率为４０％，无转移的阳性率为６６６７％（Ｐ＜００５）。提示：Ｐ１６抑癌基因能够抑制肿瘤的生长，在防止肿瘤发生发展及转移中起着重要作用。
Expression of suppressor gene P 16 was investigated in 65 ovarian serous cystadenocarcinomas,18 bordeline serous cystadenomas and 17 serous cystadenomas with the method of immunohistochemistry.The positive rates of P 16 in ovarian serous cystadenocarcinoma,bordeline serous systadenoma and serous cystadenocarcinoma were 44.62%,66.67% and 76.47% ( P <0 005) respectiver and in high(Ⅰ),middle(Ⅱ)and low(Ⅲ)three kinds of pathological differentiations,being 64%,41.38% and 27.27( P <0 005)respectively.The results showed that the positive rate of P 16 decreased with the increase of the pathological grades.There was significant difference ( P <0 05) between P 16 positive rates of lymph node and lymph node metastasis in ovarian cystradenocarcinoma.The result suggests that P 16 plays an important role in suppressing the tumor development and metastasis.Therefore,the expression of suppressor gene P 16 could be used as a marker to predict ovarian tumor biological behavior and clinical prognosis.
