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T细胞免疫和细胞凋亡在口腔扁平苔藓发病中的作用 被引量：30

Significance of cell immunoreactions and cell apoptosis in oral lichen planus
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摘要 目的通过探讨口腔扁平苔藓(OLP)中细胞凋亡情况及CD4+、CD8+T细胞和CD4/CD8比例的变化分析细胞免疫与细胞凋亡的关系,进一步了解OLP的发病机制。方法应用免疫组化SP法检测27例OLP组织中CD4+、CD8+T细胞的表达水平,并用原位末端转移酶标记法(TUNEL)定位检测17例OLP中细胞凋亡情况。结果OLP组固有层中CD4+、CD8+T细胞明显高于对照组(P<0.05),CD4/CD8值降低。OLP组中上皮内细胞凋亡指数高于对照组,固有层淋巴细胞凋亡指数明显低于对照组。结论OLP组固有层中CD4+、CD8+T细胞浸润的增加、CD4/CD8比值的变化及OLP中上皮细胞和固有层淋巴细胞凋亡异常,说明细胞免疫功能紊乱和细胞凋亡异常在OLP发病中起重要作用。 Objective To evaluate the expression of CD4^＋, CD8^＋T cells and cell apoptosis in oral lichen planus （OLP） and investigate the role and the relationship of immunological reaction and cell apoptosis in the pathogenesis of OLP. Methods Immunohistochemical technique was used to study the expression of CD4^＋, CD8^＋T cells in 27 OLP cases. TUNEL was used for detecting the cell apoptotic index （AI） in 17 OLP cases. Results The expression of CD4^＋, CD8^＋T cells were obviously elevated in lamina propria of OLP group compared with control group （P〈0.05）. There was a strong significance when compared the ration of CD4/CD8 in both group. AI was remarkably increased in epithelia ceils and significantly decreased in lymphocytes in lamina propria in OLP cases compared with its ex- pression in the control group respectively. Conclusion The increased amount of CD4^＋, CD8^＋T cells in lamina propria of OLP and the change ration of CD4/CD8 suggest that immune response is involved in the pathogenesis of OLP. The abnormal cell apoptosis plays an important role in the pathogenesis of OLP.
作者 邓冠红 陈作良 陈宏柏 程筠
机构地区 福建医科大学口腔教学医院.厦门市口腔医院口腔黏膜病科
出处 《华西口腔医学杂志》 CAS CSCD 北大核心 2009年第3期256-259,共4页 West China Journal of Stomatology
关键词 口腔扁平苔藓 细胞凋亡 CD4+T细胞 CD8+T细胞 oral lichen planus： apoptosis CD4^＋ cells： CD8^＋T cells
分类号 R781.5 [医药卫生—口腔医学]
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参考文献11

  • 1Femiano F, Cozzolino F, Gaeta GM, et al. Recent advances on the pathogenesis of oral lichen planus (OLP). The adhesion molecules[J]. Minerva Stomatol, 1999, 48 (4): 151-159.
  • 2Villarroel Dorrego M, Correnti M, Delgado R, et al. Oral lichen planus: Immunohistology of mucosal lesions[J]. J Oral Pathol Med, 2002, 31 (7) :410-414.
  • 3Khan A, Farah CS, Savage NW, et al. Th1 cytokines in oral lichen planus[J]. J Oral Pathol Med, 2003, 32(2):77-83.
  • 4刘青,金岩,吴织芬.肿瘤坏死因子α与口腔扁平苔藓[J].牙体牙髓牙周病学杂志,2000,10(4):242-244. 被引量：3
  • 5Dekker NP, Lozada-Nur F, Lagenaur LA, et al. Apoptosis-associated markers in oral lichen planus[J]. J Oral Pathol Med, 1997, 26(4) : 170-175.
  • 6Hirota M, Ito T, Okudela K, et al. Cell proliferation activity and the expression of cell cycle regulatory proteins in oral lichen planus[J]. J Oral Pathol Med, 2002, 31(4):204-212.
  • 7Neppelberg E, Johannessen AC, Jonsson R. Apoptosis in oral lichen planus[J]. Eur J Oral Sci, 2001, 109(5):361-364.
  • 8周威,金岩,吴织芬,朱萧玲,刘青.口腔扁平苔藓上皮细胞凋亡状况的分析和意义[J].牙体牙髓牙周病学杂志,2001,11(5):321-323. 被引量：12
  • 9沈丽佳,阮萍,谢方方,赵彤.Fas/FasL和颗粒酶B在口腔扁平苔藓中的表达及意义[J].第一军医大学学报,2004,24(12):1362-1366. 被引量：6
  • 10Tanda N, Mori S, Saito K, et al. Expression of apoptotic signaling proteins in leukoplakia and oral lichen planus: Quantitative and topographical studies[J]. J Oral Pathol Med, 2000, 29(8): 385-393.

二级参考文献16

  • 1[1]Sugeman PB, Savage NW, Walsh LJ, et al. The pathogenesis of oral lichen planus[J]. Crit Rev Oral Biol Med,2002, 13(4): 350-5.
  • 2[2]Neppelberg E, Johannessen AC, Jonsson R. Apoptosis in oral lichen planus[J]. Eur J Oral Sci, 2001, 109(5): 361-4.
  • 3[3]Lewinsohn DM, Bement TT, Xu J, et al. Human purified protein derivative-specific CD4+ T cells use both CD95-dependent and CD95-independent cytolytic mechanisms[J]. J Immunol, 1998, 160(5): 2374-9.
  • 4[4]Hirota M, Ito T, Okudela K, et al. Cell proliferation activity and the expression of cell cycleregulatory proteins in oral lichen planus [ J ].J Oral Pathol Med, 2002, 31(4): 204-12.
  • 5[5]Dekker NP, Lozada-Nur F, Lagenaur LA, et al. Apoptosis-associated markers in oral lichen planus[J]. J Oral Pathol Med, 1997, 26(4):170-5.
  • 6[7]Pindborg JJ, Reichart PA, Smith CJ, et al. Histological typing of cancer and precancer of the oral mucosa [M]. 2nd Edition. New York: Springer, 1996.30-7.
  • 7[9]Shimizu M, Higaki Y, Higaki M, et al. The role ofgranzyme B-expressing CD8-possitive T cells in apoptosis of keratinocytes in lichen planus[J]. Arch Dermatol Res, 1997, 289(9): 527-32.
  • 8[11]Nagata S. Apoptosis by death factor[J]. Cell, 1997, 88(3): 355-65.
  • 9[12]de Panfilis G. Activation-induced cell death: a special program able to preserve the homeostasis of the skin[J]? Exp Dermatol, 2002, 11(1): 1-11.
  • 10[13]Strauss G, Knape I, Melzner I, et al. Constitutive caspase activation and impaired death-inducing signaling complex formation in CD95-resistant, long-term activated, antigen-specific T cells [J]. J Immunol, 2003, 171 (3): 1172-82.

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华西口腔医学杂志
2009年 第3期

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