鼻内翻性乳头状瘤与人类乳头状瘤病毒的关系

THE STUDY OF RELATIONSHIP BETWEEN NASAL INVERTED PAPILLOMA AND HUMAN PAPILLOMAVIRUS

目的：探讨鼻内翻性乳头状瘤与人类乳头状瘤病毒（ＨＰＶ）的关系。方法：对２２例鼻窦和鼻腔的内翻性乳头状瘤标本分别进行免疫组织化学染色和ＰＣＲ检测。结果：２２例标本中，经免疫组织化学方法检出ＨＰＶ阳性细胞的有１１例，ＰＣＲ方法检出ＨＰＶＤＮＡ的共１７例。ＨＰＶ分型结果发现以ＨＰＶ１１、１６型最多，且以混合性感染为主。其中２例非典型增生的病例为ＨＰＶ１１／１６感染，１例复发病例为ＨＰＶ１１／１８型感染。结论：ＨＰＶ感染在鼻内翻性乳头状瘤的发生发展中具有重要地位，而且可能为一早期事件，ＨＰＶ１６、１８型与鼻内翻性乳头状瘤的复发及癌变有关。在检测上，ＰＣＲ方法优于免疫组织化学染色，值得提倡和推广。

Objective: To inquire into the relationship between the nasal inverted papilloma(IP) and human papillomavirus(HPV). Methods: HPV were detected in 22 cases of nasal IP by immunohistochemistry and polymerase chain reaction(PCR). Results: HPV positive cells were found in 11 of the 22 cases of IP by immunohistochemistry, HPVDNA was detected in 17 of the 22 cases by PCR. HPV 11, 16 was the most common type. The two cases with atypical hyperplasia were infected by HPV11/16, and the recurrence case by HPV11/18. Conclusion: Our study showed that HPV plays an etiologic role in the development of IPs, HPV16 and HPV18 probably relate to their recurrence and malignant transformation. Meanwhile, the PCR method is superior to immunohistochemistry in detecting HPV.