摘要
目的:探讨鼻内翻性乳头状瘤与人类乳头状瘤病毒(HPV)的关系。方法:对22例鼻窦和鼻腔的内翻性乳头状瘤标本分别进行免疫组织化学染色和PCR检测。结果:22例标本中,经免疫组织化学方法检出HPV阳性细胞的有11例,PCR方法检出HPVDNA的共17例。HPV分型结果发现以HPV11、16型最多,且以混合性感染为主。其中2例非典型增生的病例为HPV11/16感染,1例复发病例为HPV11/18型感染。结论:HPV感染在鼻内翻性乳头状瘤的发生发展中具有重要地位,而且可能为一早期事件,HPV16、18型与鼻内翻性乳头状瘤的复发及癌变有关。在检测上,PCR方法优于免疫组织化学染色,值得提倡和推广。
Objective: To inquire into the relationship between the nasal inverted papilloma(IP) and human papillomavirus(HPV). Methods: HPV were detected in 22 cases of nasal IP by immunohistochemistry and polymerase chain reaction(PCR). Results: HPV positive cells were found in 11 of the 22 cases of IP by immunohistochemistry, HPVDNA was detected in 17 of the 22 cases by PCR. HPV 11, 16 was the most common type. The two cases with atypical hyperplasia were infected by HPV11/16, and the recurrence case by HPV11/18. Conclusion: Our study showed that HPV plays an etiologic role in the development of IPs, HPV16 and HPV18 probably relate to their recurrence and malignant transformation. Meanwhile, the PCR method is superior to immunohistochemistry in detecting HPV.
出处
《北京医科大学学报》
CSCD
1998年第3期230-232,共3页
Journal of Peking University(Health Sciences)
关键词
内翻性乳头状瘤
乳头状瘤病毒
鼻肿瘤
病毒学
Papilloma, inverted/virology Papillomavirus, human Nose neoplasms/virology