煤工尘肺合并肺癌CT征象与病理及肿瘤标志物相关性研究

Correlation between CT signs and pathology and the serum tumor markers in lung cancer of CWP

目的:探讨煤工尘肺合并肺癌常见肿瘤标志物CEA、NSE、CYFRA21-1与肺癌的CT征象及病理类型之间的相关性。方法:分析经病理确诊的74例煤工尘肺合并肺癌患者的CT表现和血清肿瘤标志物。结果:按鳞癌联系强度依次为毛刺征、CYFRA21-1、充气征、分叶及空泡征存在直线相关与回归,P<0.05。按腺癌联系强度依次为毛刺征、分叶征、CEA、支气管气相或空泡征、胸膜凹影、存在直线相关与回归,P<0.005。小细胞癌5例与NSE存在直线相关与回归,P<0.01。结论:CT联合应用血清肿瘤标志检测结果,可进一步提高尘肺合并肺癌诊断的准确率及检出率。

Objective：To evaluate the correlation among thoracic CT, pathology and the serum tumor markers for the lung cancers of CWP. Methods：The serum tumor markers consisting of CEA, NSE and CYFRA21-1 were measured in lung cancer of CWP. The correlation analysis were performed acoording to the senventy-four patients. Results： There were linear correlation and regressive correlation between the squamous carcinoma and ground glass sign, CYFRA21-1, aerated sign, segmented, respeetirely, P 〈 0.05. There were linear correlation and regressive correlation between the adenoearcinoma and ground glass sign, segmented, CEA, air bronchus, respeetirely, P 〈 0.005. Conclusion： To use thoracic CT, pathology and the serum tumor markers together could improve diagnosis of the lung eaneers of CWP.