脑梗塞头痛患者血浆肿瘤坏死因子(TNF)水平的变化

PLASMA TUMOUR NECROSIS FACTOR LEVELS IN PATIENTS WITH HEAD ACHE DURING THE ACUTE PHASE OF CEREBRAL INFARCTION DISEASE

采用酶联免疫吸附法测定大脑中动脉区脑梗塞（ＣＩ）急性期１８例头痛患者与２２例非头痛患者和２８例对照组血浆ＴＮＦ含量，发现脑梗塞头痛组、非头痛组血浆ＴＮＦ含量（２．３３±０．２２μｇＬ、２．１１±０．２２μｇＬ）均显著（Ｐ＜０．０１）高于对照组（１．６４±０．２２μｇＬ），ＣＩ头痛血浆ＴＮＦ含量显著高于非头痛组（Ｐ＜０．０５）。研究结果提示：ＴＮＦ可能参与了ＣＩ头痛的发病过程。

Using enzyme linked immunosorbent assay(ELISA), plasma tumour necrosis factor(TNF) levels were investigated in 18 patients with headache and 22 patients without headache during the acute phase of cerebral infarction (CI) of the middle cerebral artery and in 28 patients of control group. The results showed that plasma TNF levels in patients with CI (headache 2.33±0.22μgL, nonheadache 2.11±0.22μgL) were significantly higher than those(1.64±0.22μgL) in control group (P<0.01). Plasma TNF levels were higher in patients with headache than in patients without head ache(P<0.05).These results indicated that TNF may be involved in the pathophysiology of headache that occurs at the onset of CI.