人乳头瘤病毒感染的多灶性的临床分析

Clinical screening of cervical human papillomavirus infection

对１７６例外阴尖锐湿疣患者的子宫颈进行检测，以诊断是否同时伴有人乳头状瘤病毒（ＨＰＶ）感染。结果：肉眼观察诊断宫颈ＨＰＶ感染２３例（１３％），阴道镜诊断１４６例（８３％），宫颈活检病理诊断１１２例（６４％），其中合并宫颈上皮内瘤变（ＣＩＮ）１～２级３２例（１８％）。结果提示：①外阴尖锐湿疣患者子宫颈伴有ＨＰＶ感染和／或亚临床感染相当常见。②借助阴道镜取宫颈活检是诊断宫颈ＨＰＶ感染的常用方法。③宫颈表现为糜烂者较之光滑者更多伴有ＨＰＶ感染和／或亚临床型感染。

Cervical biopsy specimens were taken from 176 women with external genital condyloma acuminata in order to diagnose a concomitant cervical human papillomavirus (HPV) infection. Positive HPV infection rate of cervix was 23(13%) by routine visual examination, 146(83%) by colposcopy and 112(64%) by pathological study. Among those patients,32(18%) had grade Ⅰ～Ⅱ cervical intraepithelial neoplasia (CIN) according to pathology. In 8 cases both vulva and cervical specimens were examined by southern blat, dot blot and polymerase chain reaction(PCR) technique HPV DNA positive was detected in 7 of 8 cervical specimens. It is concluded cervical HPV infection was rather common in women with external genital condyloma acuminata,and it is valuable to examine cervical HPV infection by colposcopy and biopsy to detect the concomitant CIN.