白首乌中C_(21)甾甙及甾甙元清除羟自由基的功能

Study on the Scavenging Effect of Baishouwu's C21 SteroidalGlycosides and Their Aglycones on Hydroxylradicals

用化学发光法研究了白首乌中Ｃ２１甾甙及各种甾甙元清除羟自由基的功能，并与具相同骨架的标准品及知名的羟自由基清除剂甘露醇进行了比较。结果表明，Ｃ２１甾甙及甾甙元具有较强的清除羟自由基的能力；Ｃ２１甾甙元的Ｃ３－ＯＨ成甙与否并不从根本上影响其活性；Ｃ２１甾甙元清除羟自由基的活性与母核上羟基取代的数目有关，而母核无清除作用。

Using a chemiluminescence assay we studied the scavenging effect of C21 steroidalglycosides and various aglycones of Baishouwu on hydroxylradicals, and compared their scavenging power with the wellknown hydroxylradical scavengermannitel and with the standard compounds having the same skeleton. The results shows that C21 steroidalglycosides and their aglycones have a strong scavenging power on hydroxylradicals ; and that whether C3—OH of the steroidal part is free or combined with glycones will not affect their activity fundamentally ; and that the active power of the aglycones is related to the number of the hydroxyl groups linked on the skeletons while the skeletons themselve have no effect.