不同分型的慢性前列腺炎对精液质量的影响

Effect of different type of chronic prostatitis on semen quality

目的研究不同分型的慢性前列腺炎(要么是由感染或是针对前列腺炎自身免疫引起)是否对精液的质量有恶化的影响。方法根据目前存在感染和/或针对前列腺的自身细胞免疫反应的情况将49个诊断为慢性前列腺炎的患者分组。健康正常的个体作为对照组。检查包括:精子的密度、死亡率、形态,前列腺与精囊标记物、抗精浆抗体、白细胞计数与伴随的炎性反应前细胞因子。结果最严重的畸形见于无明显感染而有针对前列腺的自身细胞免疫的患者中。此外,在此类患者的精浆中被检测到炎性反应前细胞因子的水平显著升高。结论此研究显示,伴有针对前列腺的自身细胞免疫反应的慢性前列腺炎患者在他们精液质量参数方面有重要的改变,并因此而引起不育。

Objective To investigate whether different type of chronic prostatitis（either caused by an infection or an autoimmune response to the prostate gland） could have a deleterious effect on semen quality. Methods Fortynine patients diagnosed chronic prostatitis were included and divided into groups according to the presence of infection and/or cellular autoimmune response against prostate antigens. Healthy normal individuals were included as controls. Measurements for sperm concentration, motility, morphology, prostate and seminal vesicle markers, antisperm antibodies,white blood cells and pro-inflammatory cytokines were performed accordingly. Results The most severe abnormalities were seen in the patients with no evident infection and an autoimmune response against prostate antigens. Moreover, significantly increased levels of pro-inflammatory cytokines were detected in seminal plasma from these patients. Conclusion The chronic prostatitis patients with cellular autoimmune response to prostate antigens present important alterations in their semen quality parameters and involved may cause male fertility.