86例新生儿败血症血清降钙素原和C反应蛋白的水平研究

Study on levels of serum procalcitonin and C-reactive protein in neonatal sepsis patients

目的探讨血清降钙素原(procalcitonin,PCT)和C反应蛋白(c-reactive protein,CRP)检测在诊断新生儿败血症中的作用。方法采用固相免疫色谱法和免疫比浊法分别测定新生儿败血症患儿的PCT、CRP浓度,并与白细胞(WBC)计数作比较。结果与对照组相比,败血症患儿中PCT和CRP水平明显升高(P<0.01),而WBC计数在两组中差异无统计学意义(P>0.05);PCT和CRP水平与患儿病情的严重程度呈正相关。结论PCT与CRP均可作为早期识别新生儿败血症及其严重性的重要指标,PCT水平检测对早期诊断与估计预后有重要意义。

Objective To evaluate the clinical significance of the detection of serum procalcitonin（PCT）and Creactive protein（CRP）in the diagnosis of neonatal sepsis. Methods Solid-phase immune chromatography and immune nephelometry were used to determine the levels of serum PCT and CRP in neonatal sepsis patients, and the testing data were compared with the levels of white blood cell count. Results The levels of PCT and CRP in the neonatal sepsis group were significantly higher than those in controls（P〈0.01）. However, the differences of white blood celll count between them were not significant（P〉0.05）. The levels of PCT and CRP were positively correlated to the severity of the illness. Conclusion PCT and CRP are both important makers for early recognizing of neonatal sepsis and the severity of the illness in the neonatal sepsis patients, PCT has important significance in early diagnosis and evaluation of patients prognosis.