COPD患者社区获得性肺炎病原学及耐药性分析

Community-acquired pneumonia pathogen and antibiotic resistance analysis of patients with COPD

目的:探讨慢性阻塞性肺疾病合并社区获得性肺炎患者(CAP)病原菌情况及其耐药性,为临床合理使用抗生素治疗提供依据。方法:分析我院86例慢性阻塞性肺疾病合并社区获得性肺炎住院患者临床资料、病原菌培养情况及其耐药性。结果:86例患者中有50例培养出病原菌,以革兰阴性细菌为主,前5位病原菌分别为铜绿假单胞菌14株,占23.7%;白色念珠菌11株,占18.6%;金黄色葡萄球菌8株,占13.6%;肺炎克雷伯菌6株,占10.2%;鲍曼不动杆菌及大肠埃希菌各4株,各占6.8%。大多数病原菌存在多重耐药性。结论:慢性阻塞性肺疾病合并社区获得性肺炎患者病原菌以革兰阴性细菌为主,目前已呈现多重耐药性,应引起临床高度重视。

Objective： To analyze chronic obstructive pulmonary disease with community-acquired pneumonia patients with pathogenic bacteria and their resistance to the rational use of antibiotics in clinical therapy. Methods Clinical data of 86 cases of chronic obstructive pulmonary disease with community-acquired pneumonia, pathogenic bacteria training situation and their resistance were analyzed. Results： 86 cases of patients developed a pathogenic bacteria in 50 cases, by gram-negative bacteria as the main bacteria,5 before the pathogen were pathogen Pscudomonas aeruginosa 14（23.7%）, Candida albicans 11（18.6%）, Staphylococcus aureus 8（13.6%）, Klchsiella pneumoniae 6（10.2%）, Acinetobacter baumannii and Escherichia coli 4 （6.8% each）. Most of pathogenic bacteria exist multiple drug resistance. Conclusion： Chronic obstructive pulmonary disease with community-acquired pneumonia patients bacteria is by gram-negative bacteria as the main bacteria,at present, there has been a multi-drug resistance to the bacteria,should attach great importance in clinic.