Effect of procainamide on ultrastructure of blood platelet in rabbits

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AIM: To study the effect of procainamide (PA) on the ultrastructure of blood platelets. METHODS: Arachidonic acid was added to PA treated platelet rich plasma to induce platelet aggregation. The 50 nm sections were examined with a transmission electron microscope. RESULTS: PA 8 5-136 μmol·L -1 markedly inhibited changes of pseudopods, α granules, dense granules, glycogens, open canalicular system,and dense tubular system. CONCLUSION: PA markedly inhibited the changes of ultrastructure of blood platelet and releasing response.