干细胞移植治疗下肢缺血性疾病的临床进展

Stem cells transplantation in ischemic disease of lower extremity

下肢缺血性疾病是一种严重危害健康的疾病。干细胞技术是21世纪最先进的技术之一，快速地应用于临床。其理论依据是干细胞为具有分化潜能的细胞，可以分化成各种机体组织细胞。自体干细胞移植正是利用这一原理，将外周血或骨髓中的干细胞移植到缺血的肢体肌肉或闭塞的血管中，使其分化、形成新生毛细血管，改善和恢复下肢血流，达到治疗下肢缺血的目的。

Ischemic disease of lower extremity is a severe disease threatening human health. In the 21st century the stem cells transplantation is one of the most advanced technologies and has applied quickly to clinical therapy. The stem cells possess the potential differentiation capability and can differentiate into all kinds of tissue cells. We transplant stem cells from peripheral blood or bone marrow to ischemic appendicular muscle or obsructed vessal in order to make them differentiate into newborn blood capillary, improve and recover blood flow of lower limb and achieve the aim of treating lower limb ischemia.