甘草酸二铵对肝病患者血糖的影响

Effect of diammonium glycyrrhizinate on blood glucose in patients with liver disease

目的研究甘草酸二铵(甘利欣)对肝病患者血糖的影响。方法对甘利欣治疗的肝病患者进行前瞻性研究,治疗前先测定其空腹血糖及餐后2 h血糖,均正常者,开始甘利欣150 mg/d,静脉点滴,然后于治疗15 d、1个月、2个月时分别复查空腹血糖及餐后2 h血糖。急性肝病疗程1个月,慢性肝病及肝硬化疗程2个月,疗程不满1月者不于统计。此外,半数患者应用生理盐水做为稀释液,半数患者应用5%葡萄糖作为稀释液,以观察不同稀释液对结果的影响。结果对血糖正常的肝病患者,无论是急性肝病、慢性肝病及肝硬化患者的血糖,在疗程两个月之内,未发现有不利影响。其稀释液,无论是生理盐水还是5%葡萄糖也都没有影响。结论甘草酸二铵(甘利欣)150 mg/d,静脉点滴,连续2个月,对血糖正常的肝病患者的血糖无不利影响。

Objective To study the effect of diammonium glycyrrhizinate （glycyrrhizin α） on blood glucose in patients with liver disease. Methods The fasting blood sugar and that 2 hours after meal were detected in patients with liver disease ; if normal, glycyrrhizin α 150 mg/d,iv,was given. Then on the 15,30,60 days after treatment, fasting and 2 hours after meal blood sugar were retested. For the acute liver diseases, the course of treatment was 1 month, and for the chronic liver diseases and cirrhosis of the liver, it was 2 months. Those who were treated less than 1 month were ruled out. In order to observe the effect of the diluent, half of the patients were given normal saline as the diluent,and half of them were given 5% glucose. Results For the patients whose blood sugar was normol, no matter they suffered from acute liver disease, chronic liver disease or cirrhosis of the liver, the therapy with glycyrrhizin α 150 mg/d,iv,for 1 -2 months had no any adverse effects on the blood sugar. The diluents,both the normal saline and the 5% glucose, also had no obvious effects. Conclusions For the patients with liver disease and normal blood sugar, glycyrrhizin α 150mg/d,iv, for 1 -2 months has no any adverse effects on the blood sugar.