米托蒽醌明胶微球对小鼠肺部S180的作用(英文)

EFFECT OF MITOXANTRONELOADED GELATIN MICROSPHERES ON S180 IN THE LUNG OF MICE

目的：测试米托蒽醌明胶微球（DHAQMS）对小鼠肺部S180肉瘤（S180）生长的靶向作用。方法：肺部接种S180七天后的小鼠，尾静脉注射DHAQMS（1．875mg·kg1·d1×2，iv～15．0mg·kg1·d1×2，iv）。接种十四天后，计数肺部瘤结节数。结果：DHAQMS能显著抑制小鼠肺部S180的生长。当实验组与阳性对照组给予相同剂量药物（DHAQ1．2mp·kg1·d1×2，iv）时，前者表现出显著高的抗癌活性（P＜0．001），当实验组药量减少一半时，仍能与阳性对照作用相当。结论：DHAQMS对肺部有显著器官靶向作用。

Objective:To test the drug mpting therapeutic dst of nitoxantoneloaded gelatin microspheres (DHAQMS) on the growth of areama 180 (S180) in the lung of mice. Methods:Kunming mice with S180 in the 1ung/d after inoculation of S180 were twed with DHAQMS(1 .875 mg.kg-1 .d-1 × 2,iv to 15 .0 mg·kg-1 .d-1 ×2, iv). 14d after inoculation, the numbers of pulmonary nodules were counted.Results: DHAQMS inhibited strongly the growth of S180 in the lung of mice.When the mice of test group and the positive contrast group(DHAQ 1 .2 mg·kg-1·d-1×2, iv)were given equal dose of DHAQ, the forme demonded markedly higher antitumor achvity(P <0. 001), and if the dose of DHAQMS was decreased by half(DHAQ 0. 6 mg·kg-1·d-1×2, iv), DHAQMS still showed the same activity as the positive control. Conclusion: DHAQMS has remarkable organtargeting effect on the lung.