柴芍承气汤对重症急性胰腺炎临床症状的改善和血清细胞因子的影响

Effect of Chaishaochengqi soup on serum cytokine and inprovement of clinical symptom for patients with severe acute pancreatitis

目的探讨柴芍承气汤对重症急性胰腺炎患者临床症状的改善和血清细胞因子的影响。方法将62例重症急性胰腺炎患者随机分为两组,对照组给予禁食、胃肠减压、补充血容量、纠正水电解质酸碱失衡、生长抑素、奥美拉唑、抗生素治疗;治疗组在对照组的基础上加用柴芍承气汤150ml经胃管注入或口服,每日2～3次。结果治疗组患者腹胀、腹痛消失时间,呼吸、心率恢复正常的时间显著低于对照组(P<0.01);治疗后两组血清TNF-α和IL-6、IL-8含量均降低,以治疗组降低最为明显,两组间比较有统计学意义(P<0.05)。结论柴芍承气汤能显著降低重症急性胰腺炎患者血清TNF-α和IL-6、IL-8水平,可以减轻胰腺炎症的全身损伤,从而明显改善重症急性胰腺炎患者腹痛、腹胀等临床症状,值得临床推广应用。

Objective To explore the effect of Chaishaochengqi soup on serum cytokine and inprovement of clinical symptom for the patients with severe acute pancreatitis. Methods 62 patients with severe acute panereatitis were divided into two groups. The control group treated with fasting, gastrointestinal decompression, supplement blood-volume,correct imbalance of water, electrolyte and acid-base, somatostatin, omeprazole and antibiotics. And the treatment group applied 150 ml Chaishaochengqi soup which poured into stomach by stomach tubes or mouth base on the former treatment in control group,twice to three times per day. Results Duration of abdominal distention and bellyache and the time for breath rate and heart rate to get normal in treatment group are all shorter than control group（ P 〈0.01）. Serrum content of TNF-α,IL-6 and IL-8 all reduced after treatment in two groups, obviously in treatment group. There are significant difference between two groups（ P 〈0.05）. Conclusion Chaishaochengqi soup could reduce the serum TNF-α, IL-6 and IL-8 level of patients with severe acute pancreatitis, and relieve the body injury caused by pancreatitis. Thereby,it could improve the clinical symptom of bellyache and abdominal distention for patients with severe acute pancreatitis obviously. It is well worth using widely in clinic.