4-甲基-3-癸烯-5-醇的合成工艺研究

Studies on the Synthesis of 4-Methyl-3-decan-5-ol

目的:改进4-甲基-3-癸烯-5-醇的反应条件及工艺路线,提高收率,使其更有利于工业化生产。方法:以正丙醛为原料,在碱性下缩合,得到2-甲基-2-戊烯醛;再以正戊醇为原料,与二氯亚砜反应得到1-氯代戊烷,然后再和镁反应制得格氏试剂正戊基氯化镁;再将2-甲基-2-戊烯醛和正戊基氯化镁反应,经过亲核取代、消除反应后,即得4-甲基-3-癸烯-5-醇。结论:所得产物经过理化性质鉴别以及结构确证,可以进一步证明与目标化合物一致,产品经GC分析,含量达98.0%以上。

Object：Improved the conditions and routes of the 4-methyl-3-decen-5-ol, this way increased the yield of the product and being morehelpful for the industrial production.Method：The first step of the synthetic pathway was obtained 2-methyl-2-pentenal by condensation of the propionaldehyde under condition of the alkali. Then raked the pentyl alchol as the raw material,reacted with thionyl chloride obtained 1-chloropentane. Which reacted with magnesium obtain Grignard reagent.The Grignard reagent reacted with 2-methyl-2-pentenal then hydrolyzed to obtain 4-methyl-3-decen-5-ol. Conclusion ： The 4-methyl-3-decen-5-ol were confirmed by 1H-NMR and IR, and the characters of physical and chemical character is according with the objective compound, the assay is more than 98.0% by GC.