盐酸多奈哌齐治疗卒中后认知功能障碍的疗效观察

The Clinical Observation of the Treatment on Poststrock Cognitive Impairment by Donepezil

目的观察盐酸多奈哌齐治疗卒中后认知功能障碍的疗效。方法67例卒中后认知功能异常的患者随机分为两组,治疗组33例,在常规治疗的基础上给予盐酸多奈哌齐5mg,每日1次;对照组34例,给予常规治疗。观察治疗前后认知功能(MMSE、MoCA)及日常生活自理能力(ADL)的改善程度。结果治疗组用药后4、12周MMSE、MoCA和ADL评分有明显改善(P<0.01),且和对照组比较,MMSE、HDS及ADL评分差异均有统计学意义(P<0.05);对照组在治疗后MMSE、HDS评分未见明显改变(P>0.05),仅ADL在治疗后12周与治疗前比较,差异有统计学意义(P<0.05)。结论盐酸多奈哌齐治疗卒中后认知功能障碍疗效确切,对患者认知功能及日常生活能力均有所改善。

Objective To evaluate the efficiency of donepezil on poststrock cognitive impairment. Methods 67 patients with poststrock cognitive impairment were randomly divided into 2 groups ： the treated group （33 cases） and the control group （34 cases）. Patients in treated group were given donepezil （5mg, once daily） in the foundation of conventional therapy ; and control group was treated by conventional therapy, taking 12 weeks clinical therapy. The degree of improvement for the cognitive function （ MMSE, MoCA） and the ability of taking care of oneself （ADL） were observed. Results After 12 weeks, the marks of MMSE, MoCA and ADL of the treatment group were significantly improved than that of the control group （ P 〈 0.05 ）. The study indicated that the marks of MMSE, MoCA and ADL had been improved （P 〈 0.05）. Conclusion Donepezil which can improve the cognitive function and the ability of taking care of oneself is effective for poststrock cognitive impairment.