摘要
肿瘤蛋白质组学是通过蛋白质组技术研究肿瘤细胞中蛋白质及其相互作用的新的学科。将蛋白质组学技术用于研究肿瘤的发病机制、寻找新的肿瘤诊断生物标记以及采用组织蛋白质组图谱进行早期诊断等早已引起了人们的广泛关注。肿瘤蛋白质组学可能会引起肿瘤临床实践的重大革命。本文对近年发现的肿瘤生物标记进行了回顾,分析了肿瘤蛋白质组学在肿瘤生物标记发展中的前景。
Oncoproteomics is a new subject of reseaching proteins and their interactions in a cancer cell by proteomic technologies. There is an intense interest in applying proteomics to foster an improved understanding of cancer pathogenesis, develop new tumor biomarkers for diagnosis, and early detection using proteomic portrait of samples. Oncoproteomics has the potential to revolutionize clinical practice. In this article, the discovery of cancer biomarkers in recent years is reviewed. The challenges ahead and perspectives of oncoproteomics for biomarkers development are also addressed.
出处
《胃肠病学和肝病学杂志》
CAS
2009年第6期502-504,共3页
Chinese Journal of Gastroenterology and Hepatology
