铁超负荷与非酒精性脂肪性肝病关系的研究进展

Relationship between iron overload and nonalcoholic fatty liver disease

肝脏是储存多余铁的主要器官,因此当铁超负荷时,肝脏也是首先受到损害的靶器官。尽管铁超负荷与非酒精性脂肪性肝病之间的关系仍存在争论,但越来越多的研究表明,铁超负荷在非酒精性脂肪肝的发展过程中起到了一定作用:铁离子不但可以诱发氧化应激和脂质过氧化,还会引发胰岛素抵抗,从而加重非酒精性脂肪性肝病。

As the main organ of storing excess iron, liver is the first target organ damage when iron overload. However, the relation between nonalcoholic fatty liver disease and iron overload is still controversial. More and more studies have shown that iron overload in the development of nonalcoholic fatty liver played a role： not only iron-induced oxidative stress and lipid peroxidation, hut also lead to insulin resistance, thereby aggravating the non-alcoholic fatty liver.