FasL、TRAIL及其受体DcR1在宫颈癌中的表达

Expressions of FasL,TRAIL and its death receptor in tissue of cervical carcinoma

目的:探讨FasL、TRAIL及其受体DcR1在宫颈癌中的表达及其临床意义。方法:应用免疫组化SP法对10例正常宫颈组织、18例宫颈上皮内瘤变(CIN)组织和40例宫颈癌组织中FasL、TRAIL及DcR1的表达情况进行检测,并结合患者年龄、肿瘤分化程度、组织类型、有无淋巴结转移等临床病理因素进行综合分析。结果:FasL在正常宫颈、CIN和宫颈癌组织中的表达呈递增趋势;宫颈癌组织中,FasL阳性表达随组织学分级的降低而升高;有淋巴结转移者FasL阳性表达明显高于无淋巴结转移者;TRAIL及DcR1在正常宫颈组织中的表达高于宫颈癌组织,宫颈癌组织中,TRAIL阳性表达随组织学分级降低而降低。结论:FasL,TRAIL及DcR1的异常表达在宫颈癌变过程中起到了一定的作用。

Objective：To investigate the expression of FasL and TNF-related apoptosis inducing hgand （TRAIL） and its rceptor DcR1 in tissue of cervical carcinoma.Methods：Immunohistochemical method was used to detect the expressions of FasL and TRAIL and DcR1 in 40 samples of cervical carcinoma, and 18 samples of cervical intraepithehal neoplasia （CIN）,together with 10 samples of normal cervical tissues. The level of the expression was analyzed combined with clinicopathological features of age, differentiation degree,histology type and lymph node metastasis. Results：The rate of positive expression of FasL was increased in normal cervical tissues ,cervical intraepithelial neoplasia（CIN） and cervical carcinoma ;there was a significant difference between FasL expressions and histologic grades, the higher expression rate of FasL expression were found in those poorer differentiated tumors; FasL correlated with lymphnode metastasis. The expression of TRAIL and DcR1 in normal cervical tissues were significantly higher than those in cervical carcinoma tissues. ,there was a significant difference between TRAIL expressions and histologic grades ,the lower expression rate of TRAIL expression were found in those poorer differentiated tumors. Conclusion：The deregulation of FasL,TRAIL and DcR1 in the CIN-cereieal cancer sequence suggests a possible functional role of these death ligands during cervical carcinogenesis.