榄香烯联合化疗治疗中晚期非小细胞肺癌的临床疗效观察

Clinical observation of elemene injection combined paclitaxel chemotherapy on advanced stage nonsmall-cell lung cancer

目的:观察榄香烯联合紫杉醇化疗方案治疗晚期非小细胞肺癌患者的临床疗效。方法:采取随机分组法将84例晚期非小细胞肺癌患者分为治疗组和对照组。治疗组44例给予榄香烯联合紫杉醇化疗;对照组40例给予单纯紫杉醇化疗,21天为一个周期,观察4个周期。治疗前后分别进行血常规、肝肾功能、胸CT扫描等指标检查,观察肿瘤病灶大小变化,同时记录临床症状变化及化疗毒副反应。结果:治疗组和对照组癌灶总有效率分别为29.54%和17.50%,两组间存在显著性差异(P<0.05)。在不良反应方面,骨髓抑制及及肝功能变化治疗组均显著优于对照组(P<0.01)。消化道反应及肾功能变化两组差异不明显。结论:榄香烯联合化疗治疗晚期非小细胞肺癌的疗效较单纯化疗好,可减轻化疗毒副反应,提高患者的生存质量。

Objective： To study the effects of elemene injection combined paclitaxel chemotherapy on advanced stage nonsmall-cell lung cancer. Methods： 84cases were randomly divided into two groups, there were 44 eases in therapy group which treated with elemene injection combined paclitaxel for four course, while there were 40 cases in control group treated with paclitaxel. One course was about 21days. Blood root, function of liver and kidney,ehest-CT were examined before and after treatment. The changes of cancer focus size ,clinical symptoms,qualities of life,toxic and side efects were recorded and compared. Results： The total effective rate of cancer focus in therapy group and eontrel group were 29.54% and 17.50% with significant diference（ P 〈0. 05 ）. Side elects ：bone marrow depression, function effect of liver in therapy group were befer than control group with significant diference（ P 〈0.01 ）. There was no significance between two groups in digestive tract reaction and renal function. Conclusion ： The treatment elects of therapy group are better than control group on advanced stage nonsmall-cell lung cancer, the plan of therapy group could reduced toxic and side elects of chemo-therapy and improves qualities of life.