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中国汉族人三磷酸肌苷焦磷酸酶活性的分布 被引量：1

Distribution of inosine triphosphate pyrophosphohydrolase activity in Han Chinese
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摘要 目的:研究三磷酸肌苷焦磷酸酶(ITPA)活性在中国汉族人中的分布。方法:运用HPLC法测定402名健康汉族人红细胞的ITPA活性。结果:不同性别、不同血型汉族人的红细胞ITPA活性均值差异无统计学意义(P>0.05),其ITPA活性呈双峰分布,活性缺乏率为27.6%。此外发现6例ITPA活性缺乏者,占研究总人数的1.47%。结论:中国汉族人红细胞ITPA活性呈双峰分布。 AIM： To study the distribution of inosine triphosphate pyrophosphatase （ITPA） activity in Han Chinese. METHODS： The mythrocyte ITPA activity was detected in healthy Han Chinese by HPLC assay （n = 402）. RESULTS： There was no significant difference in the mean ITPA activity between male and female of Han Chinese or among different blood types（ P 〉 0.05）, a bimodal distribution of ITPA activity was found and the frequency of the ITPA deficiency was 27.6% in Han Chinese. Furthermore, 6 cases with ITPA activity deficiency were found, accounting for 1.47 % of total healthy recipients. CONCLUSION ： The distribution of erythrocyte ITPA activity shows a bimodal distribution in Han Chinese.
作者 李维亮 辛华雯 吴笑春 李罄 熊磊
机构地区 广州军区武汉总医院临床药理科
出处 《中国临床药理学与治疗学》 CAS CSCD 2009年第4期426-431,共6页 Chinese Journal of Clinical Pharmacology and Therapeutics
基金 全军科学技术研究"十一五"计划课题(06MA131)
关键词 三磷酸肌苷焦磷酸酶 汉族 活性 inosine triphosphate pyrophosphatase Han Chinese activity
分类号 R969 [医药卫生—药理学]
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参考文献19

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二级参考文献19

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共引文献1

同被引文献15

  • 1熊晖,辛华雯,吴笑春,李高.硫嘌呤类药物遗传药理学研究进展[J].国际药学研究杂志,2007,34(5):356-360. 被引量：3
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  • 7Maeda T,Sumi S,Ueta A. Genetic basis of inosine triphosphate pyrophosphohydrolase defciency in the Japanese population[J].Molecular Genetics and Metabolism,2005,(04):271-279.doi:10.1016/j.ymgme.2005.03.011.
  • 8Marsh S,King CR,Ahluwalia R. Distribution of ITPA P32T alleles in multiple world populations[J].Journal of Human Genetics,2004,(10):579-581.
  • 9Jung YS,Cheon JH,Park JJ. Correlation of genotypes for thiopurine methyl transferase and inosinetriphos phPyrophosphatase with long-term clinical in Korean patients with inflammatory bowel disease during treatment with thiopurine drugs[J].Journal of Human Genetics,2010,(02):121-123.
  • 10Melaouhia S,Fékih M,Garat A. Allele frequency of inosine triphosphate pyrophosphatase(ITPA) and thiopurine-S-methyl transferase(TPMT) genes in the Tunisian population[J].Clin Res Hepatol Gastroenterol,2012,(02):178-184.

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中国临床药理学与治疗学
2009年 第4期

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