肝星状细胞激活与增殖相关信号转导通路在肝纤维化中的作用及机制

Effects and mechanisms of hepatic stellate cells (HSC) activation and proliferation-related signal transduction pathway in liver fibrosis

肝星状细胞激活和增殖在肝纤维化的发生过程中占有重要的地位。控制肝星状细胞的激活和增殖并逆肝纤维化的进程是抗肝纤维化研究的重点之一。本综述以肝星状细胞激活与增殖相关信号转导通路为中心,探讨其在肝纤维化发病作用方面的作用机制。通过干预细胞外信号传导通路,为研究肝纤维化的发病机制和药物治疗提供新的途径。

The activation and proliferation of hepatic stellate cell （HSC）have been considered to play an important role in hepatic fibrosis. The manipulation of the activation and proliferation of hepatic stellate cells and the process of liver fibrosis inversion are the key in anti-liver-fibrosis researches. This paper briefly reviews the hepatic stellate cells （HSC） activation and proliferation-related signal transduction pathway and explores the role in the pathogenesis of liver fibrosis. It is a new way to study the pathogenesis and therapy of liver fibrosis through intervention of HSC activation and proliferation-related signal transduction pathway.