脊髓损伤后异位骨化的危险因素

Risk factors in heterotopic ossification after spinal cord injury

[目的]探讨脊髓损伤后发生异位骨化的危险因素。[方法]将510例外伤性脊髓损伤患者根据X线片、CT检查分为异位骨化组(A组,59例)和无异位骨化组(B组,451例)。比较两组患者的年龄、性别、脊髓损伤情况、血清钙浓度、痉挛及压疮情况,分析与异位骨化相关的危险因素。[结果]异位骨化发生率为11.6%。A、B组患者的年龄、性别、血清钙浓度、压疮发生率经统计学比较无显著性差异(P>0.05)。A组患者中完全性瘫痪者及痉挛性瘫痪者、脊髓损伤位于颈髓及胸髓者,损伤程度为ASIA A、B级者与B组比较差异非常显著(P<0.01)。[结论]完全性瘫痪和痉挛性瘫痪、颈髓和胸髓以上损伤及ASIA A、B级者易发生异位骨化。

[ Objective] To evaluate the risk factors in heterotopic ossification（ HO ） after spinal cord injury（SCI）. [ Method ] Five hundred and ten cases with traumatic SCI were reviewed retrospectively, of which 59 cases were found HO around the hip by X-ray and CT scan （group A） ,and the other 451 cases without HO were looked as group B. The gender and age,the degree of SCI, serum calcium levels spasticity and pressure ulcers of the two groups were studied to explore the risk factors related to HO formation. [ Result] The incidence of HO was about 11.6%. There was no statistical significance in gender, age, serum calcium levels and pressure ulcer between group A and group B （ P 〉 O. 05 ）. There were more patients with complete SCI and spastieity in group A（P 〈 0.01 ）. There were more patients with cervical and thoracic spinal cord lesions in group A, and more with ASIA grade A and B（ P 〈0.01 ）. [ Conclusion] HO are apt to develop in patients with complete SCI and spastieity. And in those with cervical and thoracic spinal cord lesions, HO are apt to develop in patients with ASIA grade A and B.