视神经脊髓炎患者头颅磁共振成像特点

Brain magnetic resonance imaging abnormalities of neuromyelitis optica

目的分析视神经脊髓炎（neuromyelitis optica，NMO）患者头颅MRI特点。方法对27例NMO患者的头颅MRI进行回顾性分析。结果22例（81．5％）NMO患者存在不同类型的头部病灶，并可分为非特异性（7例）、非典型性（1例）、多发性硬化样（MS—like，3例）及脑室．导水管一中央管周围型（11例），但以脑室一导水管一中央管周围型最为常见（40．7％），且NMO患者颅内的病灶数与最后一次MRI检查的时间呈正相关（r=0．475，P：0．025）。结论NMO患者脑内病灶类型多样，但以脑室一导水管一中央管周围型最为常见，可能存在不同机制。对疑似病例早期进行头颅MRI检查相当必要。

Objective To investigate the changes in brain MRI scan in neuromyelitis optica （NMO）. Methods MRI images in 27 eases with NMO were examined in a retrospective study. Results Twenty-two of 27 patients （81.5%） had abnormal brain MRI findings, which were classified as nonspecific （7 cases）, atypical （ 1 case） , multiple sclerosis-like （ 3 cases） and ventricle-aqueduct-syringocoele lesions （11 cases）. The last type is the most common （40. 7% ）. Furthermore, the analysis showed that the number of brain lesions positively correlated with lag time from the onset to the last MRI scan （ r = 0. 475, P= 0. 025 ）. Conclusions Brain lesions in NMO are diverse, which might result from different pathogenesis. However, ventricle-aqueduct-syringocoele is the most common lesion. Early brain MRI examination of suspected cases is essential.