动脉灌注化疗加膀胱粘膜下注射及术后膀胱内灌注预防肿瘤复发

Methods such as Pouring Chemical Medicine into Artery Injecting Medicine into Tela Submucosa and Pouring Medicine into Bladder to Prevent the Recurrence of Carcinoma

目的:探讨膀胱癌切除术后预防肿瘤复发的治疗方案。方法:依据抗癌药物敏感试验结果,在手术前后进行动脉灌注化疗,术中切除肿瘤后于膀胱粘膜下注射丝裂霉素C和术后定期膀胱内灌注。结果:全组65例中有60例获得3年以上的随访,随访率(92.3%)。4例分别在术后19、27、37、43个月复发,复发率(6.7%)。结论:动脉灌注化疗加膀胱粘膜下注射及术后定期膀胱内灌注,可增强抗肿瘤作用,延长无瘤间期,对预防肿瘤复发远期疗效可靠,尤其对早期浅表性非浸润癌效果显著,为预防膀胱癌术后复发提供了一种新的化疗用药途径。

Objective： Searching for the treatment which prevents the recurrence of the urinary bladder carcinoma after excision. Method：According to the consequence of sensitive test ,we poured chemical medicine into artery before and after the operation , injected mitomycin C into the tela submucosa after the excision of carcinoma during the operation and pour medicine into bladder regularly after operation. Result： In all the 65 specimen group,60 got following investigation more than 3 years, the rate was 92.3%. And 4 recured in 19,27,37,43 months after operation. The rate of recurrence was 6.7%. Conclusion：The method such as pouring chemical medicine into artery, injecting medicine into tela submucosa and pouring medicine into bladder regularly after operation,which reinforce the effect carcinoma and prolong the period without tumor, are convenient. And its curative effect which prevents the recurrence of carcinoma , specially those in early period and limited, is trust worthly. It offers a new way of chemical treatment to prevent the recurrence after excision.