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窄谱UVB联合小剂量伊曲康唑治疗马拉色菌毛囊炎疗效观察 被引量:3

The Therapeutic Effect of NB-UVB with Low-Dose of Itraconazole on Malassezia Folliculitis
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摘要 目的:观察窄谱UVB联合小剂量伊曲康唑治疗马拉色菌毛囊炎的临床疗效。方法:将98例患者随机分成两组,试验组52例给予局部照射窄谱UVB,每周2次,连续4周,同时口服伊曲康唑100mg,每日1次,连服4周;对照组46例口服伊曲康唑200mg,每天1次,连服4周。结果:治疗后2周,试验组和对照组的治愈率分别为53.85%、58.70%,有效率分别为90.38%、93.48%,两组差异无统计学意义。结论:窄谱UVB联合小剂量伊曲康唑治疗马拉色菌毛囊炎可以产生协同作用,减少用药剂量。 Objective: To observe the effect of narrow - band UVB with low - dose of itraconazole on malassezia folliculitis. Method: 98 patients were divided into 2 groups randomly. The study group of 52 cases were shotted with NB - UVB twice a week for 4 weeks, and received oral itraconazole ( 100mg, qd) for 4 weeks. The control group of 46 cases were received oral itraconazole(200mg, qd) for 4 weeks. Result: The cure rates of the study group and the control group was 53.85% and 58.70% respectively. And effective rate was 90.38% and 93.48%. There was no statistical difference between two groups( P 〉 0.05 ). Conclusion : The combination of NB - UVB and low - dose of Itraconazole on malassezia folliculitis can enhance the efficacy and take lower daily dosage.
出处 《河北医学》 CAS 2009年第7期817-819,共3页 Hebei Medicine
关键词 窄谱UVB 伊曲康唑 马拉色菌毛囊炎 小剂量 Narrow band - UVB Itraconazole Malassezia folliculitis Low - dose
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  • 1Mayser P,Haze P,Papavassilis C,et al. Differentiation of Malassezia species: selectivity of cremophor EL, castor oil and ricinoleic acid for M.furfur[J]. Br J Dermatol, 1977,137(2):208-213.
  • 2Mittag H.Morphology of Malassezia-associated diseases[J]. Mycoses, 1996,39(suppl 1):13-19.
  • 3Mayser P, Gross A. IgE antibodies to Malassezia furfur, M. sympodialis and Pityrosporum orbiculare in patients with atopic dermatitis, seborrheic eczema or pityriasis versicolor, and identification of respective allergens[J]. Acta Derm Venereol,2000,80(5):357-361.
  • 4李家泰.临床药理学[M]人民卫生出版社,1998.

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