伊曲康唑致不良反应38例文献分析

Adverse drug reactions induced by itraconazole:literature review of 38 cases

目的：探讨伊曲康唑致药品不良反应（ADR）的一般规律及特点。方法：查阅《中国医院知识仓库（cHKD）全文期刊库》1994～2009年伊曲康唑致ADR的有关文献32篇（共38例），进行统计、分析。结果：伊曲康唑致ADR在19～60岁发生率较高，多发生于用药后1～7天内（60．53％），临床表现复杂多样，涉及机体多个器官或系统，主要的ADR为药疹及肝功能损害。结论：临床医师、药师应重视伊曲康唑所致ADR，坚持合理用药。

Objective： To explore the general patterns and characteristics of the adverse drug reactions （ADR） induced by Itraconazole. Methods： ADR reports （38cases） induced by itraconazole published in China Hospital Knoledge Database from 1994 to 2009 were analyzed statistically. Results：The ADR induced by itraconazole were more of ten occurred in patietns aged from 19 to 60, with 60. 53 % appearing within 1-7 day after drug use. The clinical presentation was complex and diverse, which involved different sys- tems and organs, predominantly the lesion of renal function and drug-induced skin rash. Conclusion： Clinician and pharmacists should attach great importance to Itraconazole-induced ADR in clinical practice and stick to rational drug use.