878例老年高血压病住院患者使用降血压药物状况分析

Pharmaceutical Analysis on 878 Cases of Hospitalized Patients with Senile Hypertension

目的:分析老年高血压患者降压达标时的用药状况及临床意义。方法:对住院的878例老年高血压病患者在血压降至达标时所用降压药的情况及疗效进行分析。结果:联合药物治疗的例数510例(占总例数58.09%),明显高于单一药物治疗的例数368例(41.91%);两种药物联合应用的例数304例(34.62%),明显高于三种药物联用的例数168例(19.13%);四种及五种药物联合应用的例数分别为32例(3.64%)和6例(0.68%),差异均有显著性意义,P<0.05。结论:老年高血压病患者降压达标大多需联合用药;较好的联合用药方案为钙通道阻滞剂(CCB)+血管紧张素转换酶抑制剂(ACEI)或血管紧张素Ⅱ受体阻滞剂(ARB)或β受体阻滞剂(β-RB),和CCB+ACEI或ARB或β-RB+利尿剂(DA)。

Objective： To analyze the pharmaceutical choices and clinical significances of antihypertensive drugs for patients with senile hypertension when the blood pressure reaches the normal level. Methods： Utilization and curative effect of antihypertensive drugs used in 878 hospitalized patients with senile hypertension when the blood pressure reached the normal level were analyzed. Results： 510 Cases in drug combination （58.09%） were obviously higher than 368 cases in single drug （41.91%）. 304 Cases in a combination of two drugs （34.62%） were obviously higher than 168 cases （19.13%） in that of three drugs, 32 cases （3.64%） in four drugs and 6 cases （0.68%） in five drugs. The differences had obvious significance （P 〈 0.05）. Conclusion： The treatment for patients with senile hypertension needs drug combination. In the antihypertensives combination, CCB and ACEI/ARB/β-RB or CCB and ACEI/ ARB/β-RB and DA are the better choices.