烟酸缓释片对老年高血压患者合并血脂异常治疗的临床观察

Clinical Efficacy of Extended-release Nicotinic Acid in Senile Hypertension Patients with Dyslipidemia

目的:探讨烟酸缓释片对老年高血压人群血脂异常的疗效和安全性。方法:按照WHO/ISH高血压指南的标准和我国血脂异常防治建议,从我院进行健康体检的年龄在60岁以上的老年人中选取217例血脂异常的高血压患者,给予烟酸缓释片治疗,第1～4周剂量为每晚1次0.5g,5～12周剂量为每晚1次1.0g,12周后观察TC、TG、LDL-C、HDL-C的变化,记录药物不良反应。结果:烟酸缓释片治疗12周后,TC、LDL-C、TG分别下降了34%、37%和47%,HDL-C升高36%,具有显著性差异(P<0.05)。TC、LDL-C、TG、HDL-C的达标率分别为28%、23%、36%和35.6%。217例中11例皮肤轻度潮红,4例胃肠道不适,未出现肌痛、横纹肌溶解现象。结论:对于老年高血压患者,烟酸缓释片能全面有效的改善血脂异常,且有良好的耐受性。

Objective： To investigate the efficacy and safety of extended-release nicotinic acid in the senile hypertension patients with dyslipidemia. Methods： According to the definition which was recommended by WHO/ISH and dystipidemia prevention and cure suggestion in China, a survey was carried out among 217 patients with dyslipidemia and hypertension above 60 years old, who were taken health examination in PLA general hospital. The patients were orally given extended-release nicotinic acid 0.5 g every night from the first week to the fourth week, and then 1.0 g every night for the following eight weeks. After 12 weeks, the changes of TC, TG, LDL-C, HDL-C and the drug adverse reactions were observed. Results： TC, TG, LDL-C decreased 34%, 37% and 47% respectively, and HDL-C increased 36% after 12 weeks treatment with extended-release nicotinic acid. There were significant differences before and after treatment （P 〈 0.05）. The achieved standard rate of TC, LDL-C, TG, HDL-C were 28%, 23%, 36% and 35.6%. Myosalgia and rhabdomyolysis didn＇t appear among the 217 patients, while 11 patients appeared slightly skin flush and 4 patients had complaint of gastrointestinal tract. Conclusion： Extended-release nicotinic acid could improve dyslipidemia effectively and all sidedly in senile hypertension patients and showed a good tolerability.