217例药品不良反应报告分析

Analysis of Adverse Drug Reactions in 217 Cases

目的:探讨我院药品不良反应发生的特点及一般规律。方法:对我院2004年1月-2007年7月收集到的217例报告从患者年龄及性别分布、给药途径、涉及药品、累及的器官或系统及临床表现等进行统计、分析。结果:217例ADR报告中,涉及药品53种,其中194例ADR是由35种抗微生物药引起,占89.40%;皮肤及附件损害148例(占39.26%),其次为消化系统反应50例(13.26%);新的和严重的ADR20例(9.22%)。结论:应合理使用抗微生物药,加强药品不良反应监测工作,保障用药安全。

Objective： To investigate the characteristic and common regularity of the adverse drug reactions in our hospital. Methods： A total of 217 ADR cases collected in our hospital during the period 2004 - 2007 were analyzed statistically in respect of distribution of age and gender, the routes of administration, the drugs involved, the organs and systems involved and the clinical manifestations etc. Results： 53 Kinds of drugs were involved in the total 217 ADR cases, with 194 cases induced by 35 kinds of antibiotics （occupied by 89.40%）. Damages of skin and its appendants took the lead （148 cases, occupied by 39.26% ）, followed by gastrointestinal symptoms （50 cases, 13.26%）. 20 Cases were new or serious ADRs （9.22%） . Conclusion： More attention should be paid to rational use of antibiotics and the monitoring of ADRs should be strengthened furtherly to ensure safe medication.