老年人颈动脉粥样硬化与MMP-9基因多态性探讨

Relationship between Matrix Metalloproteinase-9 Polymorphism C1562T and Carotid Artery Arteriosclerosis in Aged People

目的:探讨老年人颈动脉粥样硬化与基质金属蛋白酶-9(MMP-9)基因多态性关系。方法:年龄大于65岁患者96例,检测其颈动脉,依检测结果分颈动脉正常组、颈动脉内膜增厚+稳定斑块组、不稳定斑块组,并应用聚合酶链反应-限制性片段长度多态性分析法分析3组患者的MMP-9基因多态性。结果:颈动脉不稳定斑块组与正常组、内膜增厚+不稳定斑块组两组比较,不稳定斑块组C/T+T/T基因型分布、T基因频率差异有统计学意义(P<0.05)。结论:老年人颈动脉不稳定斑块与MMP-9基因多态性关系密切。

Objective： To investigate the association of matrix metalloproteinase-9 （MMP-9） polymorphisms C1562T with carotid artery arteriosclerosis in aged people. Methods：Intimalmedial thickness was determined by B ultrasound in 96 aged people. Genotype was determined by polymerase chain reaction-restriction fragment length polymorphism for screening C1562T polymorphism of MMP-9 gene. Results： Significant diffence was observed in those with carotid artery vulnerable plaques. No significant diffence was observed between those without carotid artery arteriosclerosis and those with carotid artery plaque rupture. Conclusion：There is a consanguineous relationship between vulnera- ble plaques and MMP-9 polymorphisms.