糖脂清对实验性高胆固醇血症家兔脂代谢的影响

Effect of Tangzhiqing on Serum Lipid Metabolism in Rabbits of Hypercholesterolemia

目的:观察糖脂清(TZQ)对实验性高胆固醇血症家兔脂代谢的影响。方法:采用高脂饲料喂养法建立实验性高胆固醇血症家兔模型。糖脂清用药剂量为生药3.2,1.6,0.8g·kg-1,以血脂康0.13g·kg-1作为阳性对照,给药30d后检测血清及肝脏总胆固醇(TC)、甘油三脂(TG)、血清游离脂肪酸(FFA)水平。结果:糖脂清能显著降低实验性高胆固醇血症家兔TC,TG,血清FFA水平,与模型组比较有显著差异(P<0.05,P<0.01)。结论:糖脂清对实验性高胆固醇血症家兔的脂质代谢紊乱有良好的调节作用。

Objective：To observe the effect of Tangzhiqing （TZQ） on lipid metabolism in hypercholesterolemia rabbits. Methods ： The model of hypercholesterolemia rabbit set up by feeding hypercholesterol diet. Then we used TZQ to treat the Hypercholesterolemia rabbits for 30 days at the dose of 3.2, 1.6, 0.8 g crude drug· kg^- 1, compared with Xuezhikang（0.13 g· kg^- 1 ）. At the end, the serum and hepatic total cholesterol （ TC）, triglyceride （TG） and the serum FFA were measured. Results： Compared with the model group, the levels of TC, TG and FFA obviously decreased by TZQ （ P 〈 0.05, P 〈 0.01 ）. Conclusion：TZQ could effectively regulate lipid metabolism.