小剂量十一酸睾酮治疗弱精子症41例报告

Low Dose Androil on the Treatment of Asthenospermia(Report of 41 Cases)

目的：讨论睾酮对精子活动的影响。方法：41例弱精子症患者口服十一酸睾酮（商品名：安特尔）治疗。患者平均年龄（33±6）岁，不育时间平均（4±3）年。结果：41例中，9例女方受孕，6例失访，3例未遵医嘱用药。26例用药超过3个月。26例治疗前精液体积为（2．90±0．60）ml，精子密度为（70．31±68．13），a级（9．54±4．74）％，b级（17．42±8．99）％，a级＋b级（26．96±12．22）％。治疗后1、2、3个月，精液体积、密度、a级、b级、a级＋b级精子百分比分别为（2．91±0．49、3．00±0．56、2．77±0．45）ml、（47．04±29．81、40．73±25．38、34．15±20．23）×10^6、（17．27±7．23、22．96±8．48、27．04±10．62）％、（28．00±9．05、32．77±9．97、34．96±12．45）％、（45．27±13．36、55．73±11．16、62．00±10．95）％。采用ANOVA、LSD检验分析组间差异，结果显示在0．05水平，精子密度、活动度治疗前后不同时间的差异均有统计学意义（P〈0．05）。随着用药时间的推移，药物对精子密度、恬动度的影响逐渐降低。用药后第1个月，精子活动度变化最明显，用药后第2个月与第3个月相比，精子活动度差异无统计学意义（P〉0．05）。结论：十一酸睾酮可以引起精子密度下降，精子活动度增加，值得临床采用。

Objective：To discuss the impact of testosterone on sperm motility. Methods： 41 cases with athenospermia were treated with oral andriol. The mean age of patients were （33±6） years old, the mean time of infertility were （4 ± 3） years. Results：9 males＇ wife pregnant in treating process and 6 men missed follow-up. 3 cases did not take medicine as prescribed. 26 cases took medicine more than 3 months. The volume, and motility of semen in 26 cases before treatment were （2.90±0.60）ml and （70.31±68. 13）%, The percentage of class A, class B, class A＋ B were （9.54 ± 4.74） %, （ 17.42 ± 8.99） %, and （26.96 ± 12.22） %, respectively. The volume, motility of semen, percentage of class A, class B, class A＋B in 26 cases after 1, 2, 3 months treatment were tested as （2.91±0.49, 3.00±0.56, 2.77±0.45）ml, （47.04±29.81, 40.73±25.38, 34.15±20. 23） ×10^6, （17.27± 7.23, 22.96±8.48, 27.04±10.62）%, （28.00±9.05, 32.77±9.97, 34. 96 ±12. 45 ） % , （45.27±13.36, 55.73±11.16, 62.00± 10.95）%. The data were analyzed with ANOVA and LSD. The results showed that sperm density, activity at different times before and after treatment were statistically significant at the level of 0. 05（P〈0. 05）. With the time of using medicine, the impact of the medicine on sperm density, activity de- creased. In the first month after taking medicine, the sperm activity changed the most obviously. Compared the second month and third month after taking medicine, the sperm activity was no of significant difference （P〉 0.05）. Conclusions： Andriol can cause the decrease of sperm count and the increase of sperm activity, and it worthy of clinical application.