血浆置换在儿童紫癜性肾炎和过敏性紫癜治疗中的应用

Plasmapheresis therapy in children with Henoch-Schenlein nephritis and Henoch-Schnlein purpura

过敏性紫癜(Henoch-Schnlein purpura,HSP)是一种IgA介导的全身性小血管炎。紫癜性肾炎(Henoch-Schnlein purpura nephritis,HSPN)是HSP最严重的一种并发症,也是儿科最常见的继发性肾小球疾病。血浆置换能直接和快速地清除一些直接导致疾病的致病因子,广泛应用于免疫性和代谢性疾病。文章回顾了血浆置换在儿童紫癜性肾炎和伴有严重合并症的过敏性紫癜中的治疗进展。

Henoch-Schonlein purpura （HSP） is a general vasculitis mediated by lgA. Henoch-Schonleln purpura nephritis （HSPN）, the commonest secondary glomerulopathy, is the most severe complication of HSP. Plasmapheresis is widely utilized in treating immunological and metabolic disease because it can directly remove the causative agent. Authors reviewed the recent advances in plasmapheresis in the treatment of HSPN and HSP-associated severe complications.