受精与受精失败

Fertilization and its failure

受精在辅助生育技术中是极为重要的。受精是精子和卵子相互作用的结果，是妊娠发生的开始，其过程十分复杂。精子、卵子或其相互作用的缺陷都可能导致受精障碍。正常体内受精与辅助生育技术的体外受精是有差异的。后者让不一定健康的父母尽可能生育健康宝宝，并非单纯传宗接代，是人类生殖研究的一大进步。但目前在技术上也存在不足，应予重视，需要改进。

Fertilization is crucial in assisted reproductive technology, and its process is complicated. Fertilization failure could be caused by sperm, oocyte or the reciprocity between them. It＇s different between in vivo and in vitro fertilization. The final aim of ART is getting healthy babies, even when the parents were not so healthy. ART has been a huge progress in the field of human reproduction, however there is some space to be explored in technique and safety. The traditional medicine or surgery for treatment of male infertility was a little. Since 1988 SUZI,PZD and ICSI were introduced to ART, only ICSI was proved efficient. The first ICSI baby in China was born in Sun Yat-sen University in 1996. Since then, the technique spread all over the country by training courses. The safety and the indication of ICSI have been considered, such as according to sperm parameter to choose among IUI, IVF and ICSI. Is it indication for ICSI that non-male factors like aging women, poor quality and quantity of oocytes or idiopathic infertility？ Is half ICSI, late ICSI or ICSI after a previous fertilization failure cycle necessary？ Could ICSI take over IVF？ The focus is how we can avoid fertilization failure. We should pay more attention to practice and research on fertilization and its failure. The workshop was designed to discuss the puzzle on fertilization for colleagues. The experts will share their experience in this workshop. I hope it will benefit all of you.