摘要
目的探讨肥胖症患者的骨密度(BMD)与体重指数(BMI)、脂肪量(FAT)、瘦体质量(LEAN)体质成分及其相关性。方法肥胖症组150例,其中男75例,中位年龄46岁,平均体重(89.64±8.33)kg;女75例,中位年龄45岁,平均体重(77.23±6.85)kg;正常对照组150名,其中男75名,中位年龄47岁,平均体重(62.34±5.72)kg;女75名,中位年龄45岁,平均体重(50.16±5.06)kg。分别测量2组身高、体重,计算BMI,并与双能X线吸收测量仪(DEXA)检测的各项数据进行对比及相关性分析。所获数据采用成组设计t检验,双变量间相关性采用Pearson直线相关分析。结果男性肥胖组的上肢、下肢、躯干、全身FAT分别为(2.90±0.57)、(7.48±1.46)、(15.67±3.05)、(30.92±5.94)kg,脂肪百分比(FAT%)分别为(30.9±5.1)%、(30.6±5.8)%、(37.3±4.7)%、(35.1±4.4)%,明显高于对照组[FAT分别为(1.12±0.64)、(3.27±1.22)、(6.71±3.29)、(11.61±5.16)kg,FAT%分别为(15.4±4.8)%、(16.5±5.0)%、(21.8±5.8)%、(18.6±5.3)%],P值均〈0.01;男性肥胖组躯干和全身LEAN分别为(27.65±4.08)、(57.09±7.08)kg,BMD分别为(0.99±0.09)、(1.22±0.09)g/cm^2,明显高于男性对照组[LEAN分别为(22.89±1.68)、(48.89±3.72)kg,BMD分别为(0.89±0.07)、(1.15±0.06)g/cm^2],P值均〈0.01;男性肥胖组上肢和下肢LEAN分别为(6.22±0.92)、(17.31±2.65)kg,BMD分别为(0.92±0.04)、(1.31±0.09)g/cm^2,与对照组[LEAN分别为(5.99±0.72)、(16.83±1.67)kg,BMD分别为(0.90±0.08)、(1.29±0.09)g/cm^2]比较差异无统计学意义(P值均〉0.05)。女性肥胖组的上肢、下肢、躯干、全身FAT分别为(3.78±1.53)、(12.61±3.72)、(17.56±2.59)、(33.71±6.96)kg,FAT%分别为(33.8±4.0)%、(40.1±6.9)%、(43.9±4.9)%、(43.5±4.2)%,LEAN分别为(7.28±0.94)、(14.40±2.05)、(20.71±3.08)、(43.43±5.69)kg,BMD分另0为(0.86±0.08)、(1.27±0.12)、(0.95±0.14)、(1.19±0.09)g/cm^2,均明显高于女性对照组[FAT分别为(2.04±0.79)、(3.79±0.94)、(6.89±2.56)、(14.68±3.57)kg,FAT%分别为(27.2±4.5)%、(29.6±3.9)%、(31.0±3.8)%、(25.9±4.9)%,LEAN分另4为(5.25±0.63)、(10.65±1.44)、(16.65±1.50)、(33.10±3.22)kg,BMD分别为(0.78±0.04)、(1.11±0.09)、(0.82±0.07)、(1.05±0.07)g/cm^2],P值均〈0.01。结论肥胖症患者体质成分变化主要为身体各部位脂肪组织显著增多;男、女性均以躯干部位脂肪异常增加比较明显;FAT、LEAN等体质成分变化对BMD有明昆的影响。
Objective To study the correlation of the bone mineral density (BMD) and the body composition components of body mass index (BMI) ,FAT and LEAN in Chinese obesity. Methods There were 150 cases in obesity group diagnosed by BMI, including 75 males[ median age 46 years, mean weight (89. 64 ± 8.33 ) kg] and 75 females [ median age 45 years, mean weight ( 77.23 ± 6. 85 ) kg ]. There were 150 persons with normal BMI in the control group, including 75 males [ ( median age 47 years, mean weight (62. 34 ±5.72) kg] and 75 females[ median age 45 years, mean weight (50. 16 ± 5.06) kg]. The body height and weight of 300 persons in two groups were measured respectively and, simultaneously calculated the BMI. These data and the body composition parameters measured by the dual energy X-ray absorptiometry (DEXA) in these two groups were compared and analyzed. The data obtained used two-sample t-test analysis, bi-variable correlation used Pearson linear correlation analysis and multi-variable correlation used multiple linear regression analysis. Results FAT of arms, legs, trunk and total body of male cases in obesity group was ( 2.90 ±0. 57 ) , ( 7.48 ± 1.46 ) , ( 15.67 ± 3.05 ), ( 30. 92 ± 5. 94 ) kg respectively, FAT% was ( 30. 9 ± 5.1 ) %, ( 30. 6 ± 5.8 ) %, ( 37.3 ± 4. 7 ) %, ( 35.1 ±4.4 ) % respectively, it was significantly higher than that in control group [FAT was(1.12 _±0.64), (3.27 ± 1.22), (6.71 ±3.29), (11.61 ± 5.16) kgrespectively,FAT% was(15.4±4.8)%,(16.5 ±5.0)%,(21.8 ±5.8)%,(18.6±5.3)% respectively] ,P 〈0. 01 ;LEAN of trunk and total body of male cases in obesity group was (27. 65 ±4. 08) , (57.09 ± 7.08 ) kg respectively ; BMD was ( 0. 99 ± 0. 09 ), ( 1.22 ± 0. 09 ) g/cm^2 respectively, it was significantly higher than that in control group [ LEAN was (22. 89 ± 1.68 ), (48.89 ± 3.72 )kg respectively, BMD was(0. 89 ±0. 07), (1.15 ± 0. 06) g/cm^2 respectively], P 〈 0. 01 ; LEAN of arms and legs of male cases in obesity group was ( 6. 22 ±0. 92 ), ( 17. 31 ±2. 65 ) kg respectively; BMD was ( 0. 92 ±0. 04 ), (1.31 ± 0. 09)g/cm^2 respectively, and there were no statistical significance compared with those in control group [ LEAN was ( 5. 99 ±0. 72 ), ( 16. 83 ± 1.67 ) kg respectively, BMD was ( 0. 90 ± 0. 08 ), ( 1.29 ± 0. 09) g/cm^2 respectively ]. FAT of arms, legs, trunk and total body of females in obesity group was ( 3. 78 ± 1.53 ), ( 12. 61 ± 3. 72 ), ( 17. 56± 2. 59 ), ( 33. 71± 6. 96 ) kg respectively, FAT% was ( 33. 8 ± 4.0)%,(40.1±6.9)%,(43.9 ±4.9)%,(43.5 ±4.2)% respectively, LEAN was(7.28 ±0.94), ( 14.40 ± 2.05 ), ( 20. 71 ± 3.08 ), ( 43.43±5.69 ) kg respectively, BMD was ( 0. 86 ± 0. 08 ), ( 1.27 ± 0. 12) , (0. 95 ±0. 14), ( 1.19 ±0. 09 ) g/cm^2 respectively, they were significantly higher than those in control group [ FAT was ( 2.04 ± 0. 79 ), ( 3.79 ± 0. 94 ), ( 6. 89± 2. 56 ), ( 14. 68 ± 3.57 ) kg respectively, FAT% was (27.2 ±4. 5)% ,(29.6±3.9)%, (31.0 ±3.8)%, (25.9 ±4. 9)% respectively,LEAN was (5.25±0.63), ( 10. 65 ± 1.44), ( 16. 65 ± 1.50), (33.10 ± 3.22) kg respectively, BMD was (0. 78 ± 0.04), (1.11±0.09), (0.82±0.07), (1.05 ±0.07) g/cm^2 respectively],P 〈 0. 01. Conclusion The significantly increasing of fat tissue in all parts of body is a major cause of change of body composition components in obesity. FAT in the trunk increases more obviously than that in other parts of the body in both males and females. The change of distribution of FAT and LEAN can obviously influence BMD.
出处
《中华放射学杂志》
CAS
CSCD
北大核心
2009年第6期579-584,共6页
Chinese Journal of Radiology
基金
广西自然科学基金资助项目(桂科基0575073)